More than 450 years ago, an Italian nun became the first woman to paint the iconic subject.

A copy of the famous statue can be found in this Florence piazza, along with one of the most breathtaking views of the city below.

A medieval weapon rumored to have been used by the brilliant poet himself.

Secret refuge and museum of the Duke of Florence.

This bronze boar's snout has been rubbed to a golden sheen by visitors seeking good fortune.

The famous sculptor left his mark on this Italian wall in an internationally protected example of street art.

The doodles of a genius line the walls of a secret room under the Medici Chapel, where they were hidden for nearly 500 years.

The middle finger of modernity.

The wreckage of a tragic plane crash is on display at this museum devoted to a famous Italian conspiracy.

Legend has it this fountain built to symbolize the Pope’s power hides a strange secret concerning Neptune's manliness.

The mummified relic of St. Catherine sits forever on a golden throne.

A small window on Via Piella offers a lovely and rare peek at Bologna's lost canals.

This small Milan street is filled with colorful homes and a rich history.

Da Vinci's equestrian statue, 500 years in the making.

The train platform where Jews were sent to concentration camps is now preserved as a Holocaust memorial.

Before there were doorbells this bronze ear was installed for visitors to announce their arrival.

Small on the outside, big on the inside, this church is an astonishing act of visual deception.

Just across from the "Last Supper" painting is the famous painter's vineyard, a gift received for creating the masterpiece.

One of the world’s smallest bars, just 13 square feet, is brimming with speakeasy flair.

A Milanese café entirely designed by the American director Wes Anderson.

The small peaceful island off the Venice tourist circuit is where the city began more than 1,500 years ago.

Two stone columns flank the grand Venice square, but there were supposed to be three.

This palatial spiral staircase was so unusual the name "snail" was given to the noble family who built it.

Go inside to really appreciate this 500-year-old technological masterpiece.