A sign at the end of the Santa Monica Pier marks the traditional end of the legendary American highway.

An acoustic anomaly with a mysterious cause.

Only museum dedicated to women pilots, with personal artifacts from Amelia Earhart and other aviatrixes.

A clear blue swimming hole with hidden caves, still unexplored.

The top of a giant mesa, just outside of Amarillo, appears to float in the sky above.

A sculpture made of 10 Cadillacs as a monument to the "Golden Age" of the American automobile.

A big museum full of little worlds.

Quirky water tower advertises the long-gone Brooks Tomato Products Co.

What was meant to be a temporary exhibit is now a permanent fixture at the St. Louis Zoo filled with beautiful birds.

The Old Courthouse takes visitors on a captivating trip through St. Louis' timeline.

A kitschy, creepy St. Louis mainstay.

Speak to a companion on the other side of the room loud and clear through this architectural anomaly.

Less a museum than a bizarre fantasy world created by artists and engineers.

The famous author's birthplace is preserved in a town that he once described as narrow-minded.

The clothes-washing king doubles as a community center with some unusual features, including an aviary filled with finches.

This shop for all your super spy needs hides an educational secret.

This tiny historic jail along Route 66 is the perfect fit for exactly one criminal and their partner-in-crime.

This historic Illinois "Muffler Man" has been converted from axe-touting lumberjack to rocket-wielding space ace.

Tour the luxe "glass cage" that inspired and unnerved the architecture world upon its debut.

Former hotel turned into haunted playground.

A mysteriously dark cemetery monument fuels stories and legends galore.

The oldest university museum west of the Mississippi retains its 19th century feel.

A place of great reverence for Trekkies everywhere, a hero's future birthplace.

Lured here by the promise of tens of thousands in gold, Jesse James started a quintessentially American trend of robbing trains in-motion.